Following research documenting associations between phthalate plasticizers and adverse health effects, many manufacturers are switching to chemical substitutes that are non-phthalate plasticizers. These include citrates, sebacates, adipates, and phosphates such as ATBC, DINCH, DOTP, ESBO, Mesamoll II, COMGHA, and TETM [1].

These alternative plasticizers are used in the same types of food contact materials as phthalates, especially in flexible vinyl plastic and some synthetic rubbers. These materials are often used in dairy inflations, plastic tubing, conveyor belts, cap gaskets and other seals.

Potential harm: Like phthalates, the alternative plasticizers also migrate out of processing and packaging materials in to food and beverage products. Human exposure is increasing as use increases. Although research suggests they are less hazardous than most ortho-phthalates [2], alternative plasticizers are not low hazard chemicals and some data gaps remain, especially for endocrine disruption. Epidemiological studies are lacking for these substances, and their safety for use in food contact materials remains insufficiently explored [1, 3].

Status and trends: There are few restrictions in place for non-phthalate plasticizers. However, there are growing concerns around all uses of PVC plastic. While regulatory trend is lagging, scientific scrutiny of non-phthalate plasticizers continues to grow.

Alternatives: Material substitution is recommended (i.e., replacing chemical plasticizers with flexible materials). By switching to non-vinyl plastics, such as PLA and polyethylene, most consumer exposure to plasticizer chemicals can be prevented.